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Iridium-catalyzed enantioselective addition of an N-methyl C–H bond to α-trifluoromethylstyrenes via C–H activation.
- Source :
-
Chemical Communications . 11/18/2021, Vol. 57 Issue 89, p11787-11790. 4p. - Publication Year :
- 2021
-
Abstract
- The Ir-catalyzed enantioselective addition of an N-methyl C–H bond of 2-(methylamino)pyridine derivatives to α-trifluoromethylstyrenes proceeded via C–H activation to give chiral γ-branched amine derivatives having a trifluoromethyl-substituted stereocenter. It was found that a bulky and electron-withdrawing group at the 3-position of 2-(methylamino)pyridines was necessary for the present C–H addition reaction catalyzed by a cationic iridium/chiral bisphosphine complex. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMINE derivatives
*PYRIDINE derivatives
*IRIDIUM
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 57
- Issue :
- 89
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 153531469
- Full Text :
- https://doi.org/10.1039/d1cc05076a