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Transition-Metal-Catalyzed Hydroxylation Reaction of Aryl Halide for the Synthesis of Phenols.
- Source :
-
Synlett . 2021, Vol. 32 Issue 19, p1891-1896. 6p. - Publication Year :
- 2021
-
Abstract
- Phenols are important components of pharmaceuticals, biologically active natural products, and materials. Here, we briefly discuss recent advances in catalytic hydroxylation reactions for the synthesis of phenols, with particular attention to our recent work. H2 O is proved to be an efficient hydroxide reagent in converting (hetero)aryl halides into the corresponding phenols under synergistic organophotoredox and nickel catalysis. Aryl bromides as well as less reactive aryl chlorides show high reactivity in this catalytic system. This methodology can be applied to the efficient synthesis of diverse phenols and allows the hydroxylation of multifunctional pharmaceutically relevant aryl halides. 1 Introduction 2 Representative Methods for Transition-Metal-Catalyzed Hydroxylation of (Hetero)Aryl Halides 3 Organophotoredox/Ni Dual Catalytic Hydroxylation of Aryl Halides with Water 4 Summary and Outlook [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYDROXYLATION
*PHENOLS
*PHENOL
*ARYL halides
*ARYL chlorides
*ARYL bromides
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 32
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 153605251
- Full Text :
- https://doi.org/10.1055/a-1608-5069