石斛属植物抗肿瘤活性成分及其机制研究进展.

Dendrobium is the second largest genus of Orchidaceae. Many species of Dendrobium are traditional valuable medicinal plants and have pharmacological activities in antitumor. In recent years, remarkable progress has been made in the antitumor researches of Dendrobium species. The main antitumor ingredients, extraction methods and antitumor mechanisms of Dendrobium species were summarized in this paper. The main antitumor active ingredients of Dendrobium are polysaccharides, alkaloids, phenanthrenes, benzyls and fluorenones. The antitumor mechanisms of Dendrobium species mainly include enhancing body immunity, inhibiting proliferation of cancer cells, promoting apoptosis of cancer cells, regulating or blocking cancer cell cycle, antioxidation and scavenging free radicals, and changing signal pathway conduction. Based on previous researches, we further proposed that much more effort are needed on the antitumor researches of Dendrobium species. For example, exploring more antitumor Dendrobium resources and their characteristic ingredients, analyzing their antitumor mechanism, and establishing comprehensive evaluation system. This article could provide experimental and theoretical foundations for developing new antitumor medicine from Dendrobium species, and provide scientific basis for the rational and effective utilizatin of Dendrobium resources. [ABSTRACT FROM AUTHOR]