盐酸氟西汀联合奥氮平治疗对老年抑郁发作 伴顽固性疑病症患者血清 S100β 蛋白、脑源性神经 营养因子的影响.

OBJECTIVE: To probe into the effects of fluoxetine hydrochloride combined with olanzapine on serum S100β and brain-derived neurotrophic factor ( BDNF) in elderly patients with depressive episode and intractable hypochondriasis. METHODS: Totally 105 patients with depressive episode and intractable hypochondriasis admitted into Xianyang Hospital of Yan’an University from Dec. 2018 to Jun. 2020 were extracted to be divided into the observation group (55 cases) and the control group (50 cases) via random number table. The control group was treated with fluoxetine hydrochloride capsules, while the observation group received fluoxetine hydrochloride capsules combined with olanzapine tablets. The levels of S100β and BDNF were detected before treatment and after treatment of 8 weeks, depressive symptoms [ Hamilton depression scale ( HAMD)], sleep quality [ Pittsburgh sleep quality index, PSQI) and quality of life [ World Health Organization quality of life (WHOQOL-BREF)] were evaluated. The incidence of adverse drug reactions were recorded. RESULTS: After treatment, the level of S100β in the observation group was significantly lower than that in the control group, the level of BDNF was significantly higher than that in the control group, and the difference was statistically significant (P< 0. 05). After treatment, Hamilton scale score and PSQI score in the observation group were significantly lower than those in the control group, WHOQOL-BREF score and total score were significantly higher than those in the control group, with statistically significant difference (P<0. 05). The incidence of adverse drug reactions in the observation group and the control group was respectively 10. 91% (6/55) and 14. 00% ( 7/50), the difference was not statistically significant (P>0. 05). CONCLUSIONS: The clinical efficacy of Fluoxetine hydrochloride combined with olanzapine in the treatment of elderly patients with depressive episode and intractable hypochondriasis is significant, which can effectively improve the level of BDNF and reduce the level of S100β. [ABSTRACT FROM AUTHOR]