基于数据挖掘的中医药治疗急性白血病化疗后 骨髓抑制期的临床用药规律研究.

OBJECTIVE: To probe into the medication rule of traditional Chinese medicine in the treatment of bone marrow suppression stage after chemotherapy in acute leukemia. METHODS: CNKI, Wanfang database and VIP database were retrieved to collect the literature of traditional Chinese medicine in the treatment of bone marrow suppression stage after chemotherapy in acute leukemia from the establishment of the database to Dec. 2020. With the help of Excel 2019, SPSS Modeler 18. 0 and SPSS Statistics 24. 0 software, frequency analysis, flavor and meridian tropism, cluster analysis and factor analysis were statistically performed, and association rule analysis, cluster analysis and factor analysis were carried out. RESULTS: A total of 131 prescriptions were screened out, including 239 kinds of traditional Chinese medicine, the main drug taste were Ku and Gan, and the main characteristics were Han and Wen. The main channel tropisms were liver followed by spleen and kidney. Tonic drugs, heat-clearing and detoxifying drugs and blood-activating hemostatic drugs were mostly used. A total of 19 association rules were obtained, cluster analysis can be grouped into 6 categories, and 8 common factors were extracted by factor analysis. CONCLUSIONS: During the bone marrow suppression stage after chemotherapy in acute leukemia, the main treatment is spleen invigorating and kidney nourishing therapy, and to focus on fostering healthy Qi. [ABSTRACT FROM AUTHOR]