Goal-driven, neurobiological-inspired convolutional neural network models of human spatial hearing.

• Neurobiological-inspired CNN models accurately predict sound location. • Models of binaural integration in human brainstem simulate human sound localization. • Objective functions minimizing angular or Euclidean distance lead to distinct errors. • Feature representations of shallow layers resemble brainstem neuronal spatial tuning. • Neurobiological-inspired CNN models generate testable predictions for neuroscience. The human brain effortlessly solves the complex computational task of sound localization using a mixture of spatial cues. How the brain performs this task in naturalistic listening environments (e.g. with reverberation) is not well understood. In the present paper, we build on the success of deep neural networks at solving complex and high-dimensional problems [1] to develop goal-driven, neurobiological-inspired convolutional neural network (CNN) models of human spatial hearing. After training, we visualize and quantify feature representations in intermediate layers to gain insights into the representational mechanisms underlying sound location encoding in CNNs. Our results show that neurobiological-inspired CNN models trained on real-life sounds spatialized with human binaural hearing characteristics can accurately predict sound location in the horizontal plane. CNN localization acuity across the azimuth resembles human sound localization acuity, but CNN models outperform human sound localization in the back. Training models with different objective functions - that is, minimizing either Euclidean or angular distance - modulates localization acuity in particular ways. Moreover, different implementations of binaural integration result in unique patterns of localization errors that resemble behavioral observations in humans. Finally, feature representations reveal a gradient of spatial selectivity across network layers, starting with broad spatial representations in early layers and progressing to sparse, highly selective spatial representations in deeper layers. In sum, our results show that neurobiological-inspired CNNs are a valid approach to modeling human spatial hearing. This work paves the way for future studies combining neural network models with empirical measurements of neural activity to unravel the complex computational mechanisms underlying neural sound location encoding in the human auditory pathway. [ABSTRACT FROM AUTHOR]