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Fully integrated flexible biosensor for wearable continuous glucose monitoring.
- Source :
-
Biosensors & Bioelectronics . Jan2022, Vol. 196, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- Continuous physiological monitoring is a promising alternative to current chronic disease management for obtaining big data sets to help individualized therapy. Here, we present a continuous glucose monitoring platform consisting of a screen-printed electrochemical biosensor and a fully integrated wireless electrochemical analysis system. A biocompatible conjugated polymer (poly (N-phenylglycine)) was employed as the support material for enzyme immobilization. Specifically, a polyurethane outer layer was decorated onto the working electrode of the biosensor to construct a diffusion limiting membrane and improve the linear range of the glucose sensor. We optimized the fabricated glucose sensor so that it achieves a linear range of 1–30 mM and a sensitivity of 12.69 μA mM−1·cm−2 in vitro. The long-term stability is up to 30 days by storing in PBS solution at 4°C. The overall system design was very small (0.8 × 1.8 cm) and consisted of a signal conditioning part, a programmable electrochemical chip, and a wireless connection using Bluetooth Low Energy with a smartphone. Finally, we carried out biocompatibility tests and animal experiments to demonstrate the device can successfully monitor blood glucose in vivo. • A flexible, miniaturized and fully integrated wearable CGM system was fabricated. • Chemically synthesized PPG was first employed for GOx immobilization. • Exhibits an excellent linear range of 1–30 mM and long-term stability for 30 days. • The overall system design was very small (0.8 × 1.8 cm). • The biocompatibility tests and animal experiments were carried out. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09565663
- Volume :
- 196
- Database :
- Academic Search Index
- Journal :
- Biosensors & Bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 153868992
- Full Text :
- https://doi.org/10.1016/j.bios.2021.113760