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Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis.
- Source :
-
Microbiology Insights . 11/29/2021, p1-10. 10p. - Publication Year :
- 2021
-
Abstract
- Objective: To perform systematic review and meta-analysis of meningococcal disease burden in India. Methods: We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of Meningococcal meningitis and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively. Results: The prevalence of Meningococcal meningitis in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; N. meningitis caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance. Conclusion: The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11786361
- Database :
- Academic Search Index
- Journal :
- Microbiology Insights
- Publication Type :
- Academic Journal
- Accession number :
- 153894053
- Full Text :
- https://doi.org/10.1177/11786361211053344