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A New Acenaphthylene and Bioactive Constituents of Salvia arisanensis.
- Source :
-
Chemistry of Natural Compounds . Nov2021, Vol. 57 Issue 6, p991-995. 5p. - Publication Year :
- 2021
-
Abstract
- A new acenaphthylene derivative, salviarisanal (1), has been isolated from the aerial part of Salvia arisanensis, together with six known compounds, carnosol (2), 16-hydroxycarnosol (3), ferruginol (4), cryptotanshinone (5), salvileucantholide (6), and dugesin B (7). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, cryptotanshinone (5) exhibited cytotoxicities with IC50 values of 5.38, 7.16, 4.84, and 9.10 μM, respectively, against DLD-1, CCRF-CEM, HL-60, and IMR-32 cell lines. 16-Hydroxycarnosol (3) also exhibited cytotoxicities with IC50 values of 7.42 and 6.73 μM, respectively, against DLD-1 and IMR-32 cell lines. In addition, salviarisanal (1), carnosol (2), 16-hydroxycarnosol (3), and ferruginol (4) showed potent inhibition with IC50 values of 18.45, 30.33, 27.58, and 35.05 μM, respectively, against LPS-induced NO generation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SALVIA
*CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 57
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 153955174
- Full Text :
- https://doi.org/10.1007/s10600-021-03535-3