A New Acenaphthylene and Bioactive Constituents of Salvia arisanensis.

A new acenaphthylene derivative, salviarisanal (1), has been isolated from the aerial part of Salvia arisanensis, together with six known compounds, carnosol (2), 16-hydroxycarnosol (3), ferruginol (4), cryptotanshinone (5), salvileucantholide (6), and dugesin B (7). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, cryptotanshinone (5) exhibited cytotoxicities with IC50 values of 5.38, 7.16, 4.84, and 9.10 μM, respectively, against DLD-1, CCRF-CEM, HL-60, and IMR-32 cell lines. 16-Hydroxycarnosol (3) also exhibited cytotoxicities with IC50 values of 7.42 and 6.73 μM, respectively, against DLD-1 and IMR-32 cell lines. In addition, salviarisanal (1), carnosol (2), 16-hydroxycarnosol (3), and ferruginol (4) showed potent inhibition with IC50 values of 18.45, 30.33, 27.58, and 35.05 μM, respectively, against LPS-induced NO generation. [ABSTRACT FROM AUTHOR]