脱细胞真皮基质在临床治疗中的应用.

BACKGROUND: As a skin substitute, acellular dermal matrix has broad prospects and market. OBJECTIVE: To review the clinical application of acellular dermal matrix. METHODS: The authors searched PubMed, CNKI and Wanfang databases for articles published from 2000 to 2021 with the key words of “acellular dermal matrix, reconstruction/repair/plastic/clinical study” in English and Chinese, separately. Finally, 64 articles were included for review. RESULTS AND CONCLUSION: Acellular dermal matrix, characterized by rapid vascularization, low antigenicity, good histocompatibility and stable physicochemical properties, is a commonly used biological material in operations in the head and neck surgery, breast surgery, burn plastic surgery, gynecology, and urology. The main problem lies in its low output and the complicated production process to meet the medical standards. Thus, the price of acellular dermal matrix used in clinical use is high, increasing the medical economic burden of patients. Although most of the alloantigen substances are removed, acellular dermal matrix is still a foreign material for patients, so there is still a risk of surgical complications, such as rejection and infection. For future acellular dermal matrix, it is necessary to optimize the production process, improve the production process, reduce the production cost and increase the commercial specifications. From improving the decellularization process, it further removes proteins and other allergens from the acellular dermal matrix while preserving the dermal matrix, further reduces the immunogenicity of the acellular dermal matrix, enhances its compatibility, and reduces adverse events, such as infection and rejection. [ABSTRACT FROM AUTHOR]