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Defects of parvalbumin-positive interneurons in the ventral dentate gyrus region are implicated depression-like behavior in mice.
- Source :
-
Brain, Behavior & Immunity . Jan2022, Vol. 99, p27-42. 16p. - Publication Year :
- 2022
-
Abstract
- • LPS induced depression is accompanied with decline in the numbers of DG-PVIs. • CUMS induced depression is occurring with decrease in PVIs numbers in the vHPC. • Ablation of PVIs from the vDG induced depression-like behavior. • Removal vDG-PVIs induced depression potentially associated with neuroinflammation. Depression is an increasingly common but extremely serve mood disorder that remains poorly understood and inadequately treated. Fast-spiking parvalbumin-positive interneurons (PVIs), a subpopulation of GABAergic interneurons (GABA, g-aminobutyric acid), exhibit a widespread distribution throughout the hippocampus, and has been reported to play an important role in a variety of mental disorders. However, the relationship between depression and hippocampal PVIs remains unclear. Here in this present study, a series of experiments were conducted to clarify the potential relationship. Here, chronic unpredicted mild stress (CUMS) and Lipopolysaccharide (LPS) injection were introduced to induce depression-like behavior in mice, and led to a clear decline in PVIs numbers in the ventral hippocampal (vHPC), particularly in the ventral dentate gyrus (vDG) subfield. After a selectively removal of the PVIs in PV-ires-Cre::Ai14 mice, we confirmed that ablation of PVIs from the vDG induced depression-like behavior. Furthermore, we found that the removal of vDG-PVIs induced depression likely to be accounted for upregulation of neuroinflammation. These findings facilitate us better understand the role of hippocampal PVIs in depression. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08891591
- Volume :
- 99
- Database :
- Academic Search Index
- Journal :
- Brain, Behavior & Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 153974794
- Full Text :
- https://doi.org/10.1016/j.bbi.2021.09.013