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para-Selective hydroxylation of alkyl aryl ethers.
- Source :
-
Chemical Communications . 12/18/2021, Vol. 57 Issue 97, p13190-13193. 4p. - Publication Year :
- 2021
-
Abstract
- para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(II) catalyst, hypervalent iodine(III) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 57
- Issue :
- 97
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 154017292
- Full Text :
- https://doi.org/10.1039/d1cc06210g