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Associations between hair levels of trace elements and the risk of preterm birth among pregnant Wwomen: A prospective nested case-control study in Beijing Birth Cohort (BBC), China.

Authors :
Ren, Mengyuan
Zhao, Jing
Wang, Bin
An, Hang
Li, Yuhuan
Jia, Xiaoqian
Wang, Jiamei
Wang, Shuo
Yan, Lailai
Liu, Xiaohong
Pan, Bo
Li, Zhiwen
Ye, Rongwei
Source :
Environment International. Jan2022, Vol. 158, pN.PAG-N.PAG. 1p.
Publication Year :
2022

Abstract

[Display omitted] Trace elements have various physiochemical functions in humans and are associated with the occurrence of preterm birth (PB). However, their mixed effects on PB risk have rarely been studied. We aimed to investigate the associations between hair levels of trace elements and PB risk among pregnant women. A nested case-control study with a prospective cohort was conducted in Beijing City, China. We included 82 women who had a PB [total PB (tPB)] as cases [including 40 with a spontaneous PB (SPB)] and 415 who had a term delivery as controls. Hair levels of the concerned trace elements were measured including endocrine disrupting metal(loid)s [EDMs; lead, mercury (Hg), arsenic, and cadmium] and nutritional trace metal(loid)s [NTMs; zinc (Zn), iron (Fe), copper, and selenium]. Logistic regression analysis was performed to estimate the odds ratios (ORs) for PB. Bayesian kernel machine regression (BKMR) was used to assess the associations between mixed exposure to the trace elements and PB risk. Significantly lower maternal hair concentrations of Zn and Fe were observed in the SPB cases than in the controls, whereas no differences for the other trace elements. Single-element modeling results suggested second-quartile Hg maternal hair concentrations, third-quartile Zn concentrations, and fourth-quartile Fe concentrations were associated with a reduced risk of tPB with adjusted ORs of 0.43 [95% confidence interval (CI): 0.21–0.87], 0.38 (95% CI: 0.18–0.82), and 0.48 (95% CI: 0.24–0.98), respectively, compared to first-quartile values. Similar results were obtained for SPB. According to the BKMR models, hair NTMs were significantly, monotonously, and inversely associated with the risk of SPB, after controlling for covariates and levels of the four EDMs. Fe and Zn contributed the most strongly to the association. We concluded that maternal higher levels of NTMs, especially Fe and Zn, may reduce the risk of PB. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01604120
Volume :
158
Database :
Academic Search Index
Journal :
Environment International
Publication Type :
Academic Journal
Accession number :
154111167
Full Text :
https://doi.org/10.1016/j.envint.2021.106965