Very late reactions in the patch test with fragrance mix I and oak moss absolute (Evernia prunastri, INCI): Data of the Information Network of Departments of Dermatology (IVDK).

Of 131 patch-test positive patients, 24 (18.3%) reacted to both preparations, 98 (74.8%) to FMI only, and 9 (6.9%) to OM and not to FMI, although OM is a constituent of FMI. Keywords: allergic contact dermatitis; delayed reactions; fragrance; fragrance mix I; late reactions; oak moss absolute; patch test; patch test active sensitization EN allergic contact dermatitis delayed reactions fragrance fragrance mix I late reactions oak moss absolute patch test patch test active sensitization 54 57 4 12/17/21 20220101 NES 220101 Patch test reactions that become positive de novo at around day 7 (D7) are called "late" patch test reactions,1 and are frequently seen after patch testing neomycin, for example.2 Reactions beyond D7 ("very late reactions") may indicate active sensitization.1,3 However, very late reactions (2 to 4 weeks after patch testing) without being linked to active sensitization have also been observed.4-6 We were interested in very late reactions (beyond D7) in patch testing fragrance mix I (FMI) and oak moss absolute (OM). Regarding all positive reactions, 11/136 (8.1%) of FMI-positive patients and 11/45 (24.4%) of OM-positive patients showed very late reactions (Table 1). 1 TABLEResults of reading fragrance mix I (FMI) and oak moss absolute (OM) in n = 1789 patients at different points of time HT <table><thead valign="bottom"><tr><th align="left" /><th align="left">N patients</th><th align="left">Positive D3(D4)</th><th align="left">% D3(D4)</th><th align="left">Late positive D4-D7</th><th align="left">Very late positive. Allergic contact dermatitis, delayed reactions, fragrance, late reactions, oak moss absolute, patch test, patch test active sensitization, fragrance mix I. [Extracted from the article]