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The relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus.
- Source :
-
BMC Endocrine Disorders . 10/19/2021, Vol. 21 Issue 1, p1-7. 7p. - Publication Year :
- 2021
-
Abstract
- Background: The aim of the study was to explore the relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus. Methods: The participants were recruited from Hebei General Hospital. Basic characteristics and blood indicators were collected after fasting overnight. The data were analyzed statistically using SPSS 22.0. Analysis of variance, a nonparametric test, or a trend Chi-square test was used for the comparisons. The association between 25-hydroxy vitamin D and modified homeostasis model assessment-β was assessed using multivariate ordinal logistic regression. Results: One hundred seventy-four patients aged 26 to 79 years with type 2 diabetes mellitus were included in this study. Patients with vitamin D deficiency had a lower modified homeostasis model assessment-β level compared with those without vitamin D deficiency. There were differences in body mass index, diabetes course, glycosylated hemoglobin, fasting blood glucose, fasting blood C-peptide, triglyceride, and 25-hydroxy vitamin D among different modified homeostasis model assessment-β groups based upon the tertiles. 25-hydroxy vitamin D, as continuous or categorical variables, was positively related to modified homeostasis model assessment-β whether or not cofounding factors were adjusted. Conclusion: There is an association between increased 25-hydroxy vitamin D levels and improvement in modified homeostasis model assessment-β function in patients with type 2 diabetes mellitus. Trial registration: Cross-sectional trails ChiCTR2000029391, Registration Date: 29/01/2020. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FASTING
*NONPARAMETRIC statistics
*HOMEOSTASIS
*GLYCOSYLATED hemoglobin
*TRIGLYCERIDES
*ANALYSIS of variance
*MULTIPLE regression analysis
*CROSS-sectional method
*HEALTH status indicators
*BLOOD collection
*BLOOD sugar
*VITAMIN D
*ISLANDS of Langerhans
*TYPE 2 diabetes
*PUBLIC hospitals
*CHI-squared test
*DATA analysis software
*VITAMIN D deficiency
*BODY mass index
*C-peptide
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 21
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Endocrine Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 154195955
- Full Text :
- https://doi.org/10.1186/s12902-021-00862-y