497: ASSOCIATION OF WHOLE EXOME SEQUENCING WITH SEVERITY OF ILLNESS IN THE PEDIATRIC ICU.

B Introduction: b Genetic etiologies of pediatric disease represent an increasing proportion of pediatric intensive care unit (PICU) admissions due to more accessible diagnostic and therapeutic techniques. The central hypothesis is that if a PICU patient has ever had WES performed, then they will carry a higher disease burden on admission than other PICU patients. Comparing all admissions for each patient, those with WES performed demonstrated a higher median PRISM III score of 7 (IQR 3, 12) relative to the general PICU population median of 3 (IQR 0, 8) (p < 0.001). [Extracted from the article]