1440: TEMPERATURE TRAJECTORY SUBPHENOTYPES AND THE IMMUNOINFLAMMATORY RESPONSE IN PEDIATRIC SEPSIS.

Given the distinct epidemiology of pediatric sepsis, we aimed to classify septic children into I de novo i sub-phenotypes derived from temperature trajectories and compare cytokine, immune function, and immunometabolic markers across subgroups. We performed group-based trajectory modeling (GBTM) using available temperatures over the first 72 hours of sepsis to identify latent I de novo i profiles. As an alternative approach, four sub-phenotypes defined by distinct temperature trajectories have been reported in adult sepsis. [Extracted from the article]