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Kick it up a Notch: NOTCH1 activation in T-ALL
- Source :
-
Cancer Cell . Nov2004, Vol. 6 Issue 5, p431-432. 2p. - Publication Year :
- 2004
-
Abstract
- While the human NOTCH1 gene initially was cloned as part of a translocation breakpoint in T cell acute lymphoblastic leukemia (T-ALL) tumors, this translocation is present in only a small percentage of T-ALL patients. A recent paper by demonstrates that novel types of activating mutations in the NOTCH1 gene occur in more than half of all T-ALL cases, implicating NOTCH1 as a major player in the etiology of T-ALL. [Copyright &y& Elsevier]
- Subjects :
- *T cells
*LYMPHOBLASTIC leukemia
*PATIENTS
*GENETIC mutation
*ETIOLOGY of diseases
Subjects
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 6
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 15425078
- Full Text :
- https://doi.org/10.1016/j.ccr.2004.10.019