乳腺癌组织 FOXP3、HMGA2、RASAL2 的表达及与临床病理特征和预后的关系.

Objective: To investigate the expression of forkhead box P3 (FOXP3), high mobility group protein A2 (HMGA2) and ras protein activator like 2 (RASAL2) in breast cancer tissues and their relationship with clinicopathological features and prognosis. Methods: 102 cases of breast cancer patients who were treated in our hospital from June 2014 to June 2015 were selected as the research objects. The expressions of FOXP3, HMGA2 and RASAL2 in breast cancer tissues and adjacent tissues were detected. The correlation of expressions of FOXP3, HMGA2 and RASAL2 with clinicopathological parameters was analyzed. Kaplan-Meier survival curve was used to analyze the difference of the overall survival rate of patients with different expressions of FOXP3, HMGA2 and RASAL2. Cox proportional hazard regression analysis of prognostic factors in breast cancer patients. Results: Compared with adjacent tissues, the positive expression rates of FOXP3 and HMGA2 in breast cancer tissues were increased, while the positive expression rate of RASAL2 was decreased (P<0.05). The expressions of FOXP3, HMGA2 and RASAL2 were all correlated with TNM stage and lymph node metastasis (P<0.05). The survival rate of FOXP3 and HMGA2 positive patients were significantly lower than those of FOXP3 and HMGA2 negative patients, and the survival rate of RASAL2 positive patients was significantly higher than that of RASAL2 negative patients (P<0.05). TNM stage Ⅲ, FOXP3 positive expression, HMGA2 positive expression were the risk factor affecting the prognosis of breast cancer patients (P<0.05), the positive expression of RASAL2 was a protective factor for the prognosis of breast cancer patients (P<0.05). Conclusion: The positive expression rates of FOXP3 and HMGA2 in breast cancer tissues are increased, while the positive expression rates of RASAL2 is decreased. The positive expression of FOXP3 and HMGA2 and the negative expression of RASAL2 were correlated with TNM stage and lymph node metastasis in breast cancer patients, and are the influencing factors for poor prognosis of the patients. [ABSTRACT FROM AUTHOR]