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pH-driven self-assembly of alcohol-free curcumin-loaded propylene glycol alginate nanoparticles.
- Source :
-
International Journal of Biological Macromolecules . Jan2022, Vol. 195, p302-308. 7p. - Publication Year :
- 2022
-
Abstract
- The purpose of this paper was to explore the application of propylene glycol alginate (PGA) alone in alcohol-free curcumin-loaded nanoparticles (PGA/Cur) prepared by a pH-driven method to solve the curcumin shortcomings of low water solubility, stability and bioavailability. One of the bright spots of PGA/Cur was its extremely high loading capacity. PGA/Cur formed a spherical structure mainly by hydrophobic interaction and hydrogen bonding, making curcumin amorphous. PGA/Cur exhibited stability at pH 4.0–8.0 due to its high surface charges. PGA/Cur still showed a unimodal size distribution even under 3000 mM ionic strength. Heating caused uneven size distribution, but the smaller size still presented its thermostability. PGA/Cur exhibited good physical stability and slowed down the curcumin degradation with t 1/2 of 37.47 days during storage. PGA/Cur could maintain structural integrity in gastric acid and released curcumin in the intestine, thus improving the bioaccessibility of curcumin. Additionally, PGA/Cur displayed the solubilization after lyophilization. • Propylene glycol alginate alone can form nanoparticles by pH-driven method. • The perspective of carrier design is economy, simplicity, energy saving and safety. • The unique advantage of nanoparticles is high loading capacity. • The nanoparticles had good physicochemical stability and bioaccessibility. • The nanoparticles showed solubilization of curcumin after lyophilization. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 195
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 154313281
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2021.12.025