Back to Search
Start Over
A Domino Heck Coupling–Cyclization–Dehydrogenative Strategy for the One-Pot Synthesis of Quinolines.
- Source :
-
Synthesis . 2022, Vol. 54 Issue 2, p393-402. 10p. - Publication Year :
- 2022
-
Abstract
- An efficient, one-pot, domino synthesis of quinolines via the coupling of iodoanilines with allylic alcohols facilitated by palladium catalysis is described. The overall synthetic process involves an intermolecular Heck coupling between 2-iodoanilines and allylic alcohols, intramolecular condensation of in situ generated ketones with an internal amine functional group, and a dehydrogenation sequence. Notably, this protocol occurs in water as a green solvent. Significantly, the method exhibits broad substrate scope and is applied for the synthesis of deuterated quinolines through a deuterium-exchange process. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALLYL alcohol
*QUINOLINE
*FUNCTIONAL groups
*PALLADIUM
*KETONES
*DEHYDROGENATION
Subjects
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 54
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 154452095
- Full Text :
- https://doi.org/10.1055/a-1589-7548