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Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells
- Source :
-
FEBS Letters . Nov2004, Vol. 577 Issue 3, p333-338. 6p. - Publication Year :
- 2004
-
Abstract
- Receptor tyrosine kinases (RTKs) are transactivated by the stimulation of G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P), a ligand of GPCR, is known as a tumor-promoting lipid, but its signaling pathways are not fully understood. We here demonstrated that S1P induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells, both of which have been proposed as prognostic markers of gastric cancers. The pathway of S1P-induced c-Met transactivation is Gi-independent and matrix metalloproteinase-independent, which differs from that of EGFR transactivation. Our results indicate that S1P acts upstream of various RTKs and thus may act as a potent stimulator of gastric cancer. [Copyright &y& Elsevier]
- Subjects :
- *SPHINGOSINE
*EPIDERMAL growth factor
*CANCER cells
*TYROSINE
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 577
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 15449333
- Full Text :
- https://doi.org/10.1016/j.febslet.2004.10.024