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Preclinical evaluation of Zanthoxylum piperitum Benn., traditional muscle pain remedy, for joint inflammation.
- Source :
-
Journal of Ethnopharmacology . Mar2022, Vol. 286, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- Zanthoxylum piperitum has been used as a traditional Asian medicine to treat hypertension, stroke, bruise and muscle pain. It has been known to induce detoxification; affect anti-bacterial, anti-oxidant, and tyrosinase activity; inhibit osteosarcoma proliferation; anti-osteoarthritis inflammation. In this study, we aim to identify the therapeutic effect of Z. piperitum 90% EtOH extract (ZPE-LR) on rheumatoid arthritis. We investigated the anti-rheumatoid arthritis and -immunomodulatory activities of the ZPE-LR in collagen-induced arthritic (CIA) mice, a rheumatoid arthritis animal model. In order to assess the analgesic effects of ZPE-LR in vivo , acetic acid injection, formaldehyde injection, hot plate model was used. The mechanism for anti-inflammatory activity of ZPE-LR was identified with LPS-stimulated Raw 264.7 cells. Pharmacologically, oral administration of ZPE-LR into CIA mice resulted in a significant and dose-dependent decrease in clinical arthritis score and paw swelling compared to untreated negative control. Pathologic examination showed that ZPE-LR prevented morphological change in cartilage and destruction of phalanges in CIA mice. This protective effect was associated with reduced pain, inflammatory mediators such as NO, TNF-α, IL-1β, and IL-6, as well as COX-2 and iNOS expression. Furthermore, reduction of phosphor-ERK and BDNF indicates a novel rheumatoid arthritis-regulating mechanism by ZPE-LR treatment. These data suggest that the administration of ZPE-LR remarkably inhibited CIA progression and might be helpful in suppressing inflammation and pain in rheumatoid arthritis. [Display omitted] • ZPE-LR have been effectively inhibited on rheumatoid arthritis-induced pain and inflammation. • ZPE-LR prevented morphological change in cartilage and destruction of phalanges in CIA mice on pathologic examination. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLLAGEN
*NARCOTICS
*INTERLEUKINS
*CLINICAL drug trials
*MYALGIA
*IN vivo studies
*JOINT diseases
*INFLAMMATION
*ANIMAL experimentation
*ANALGESICS
*FORMALDEHYDE
*ORAL drug administration
*ANTIRHEUMATIC agents
*TREATMENT effectiveness
*RHEUMATOID arthritis
*ASIAN medicine
*IMMUNOLOGICAL adjuvants
*ACETIC acid
*TUMOR necrosis factors
*DRUG development
*PLANT extracts
*MICE
Subjects
Details
- Language :
- English
- ISSN :
- 03788741
- Volume :
- 286
- Database :
- Academic Search Index
- Journal :
- Journal of Ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 154559066
- Full Text :
- https://doi.org/10.1016/j.jep.2021.114921