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Dual Activation of Unsaturated Amides with Schwartz's Reagent: A Diastereoselective Access to Cyclopentanols and N,O‐Dimethylcyclopentylhydroxylamines.
- Source :
-
Chemistry - A European Journal . 1/13/2022, Vol. 28 Issue 3, p1-5. 5p. - Publication Year :
- 2022
-
Abstract
- The diastereoselective access to cyclopentanols and N,O‐dimethylcyclopentylhydroxylamines from 4‐pentenoic acid‐derived Weinreb amides is described. Based on the concomitant generation of both the nucleophilic and the electrophilic poles by hydrozirconation of the amide and the C=C double bond, the cyclisation may be tuned towards cyclopentanols or N,O‐dimethylcyclopentylhydroxylamines depending on the ring‐closure promotor. An extension to cis 3‐substituted N,O‐dimethylcyclohexylhydroxylamines is also presented. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DOUBLE bonds
*RING formation (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 28
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 154690514
- Full Text :
- https://doi.org/10.1002/chem.202103789