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Carotid body physiology meets cytochrome c oxidase crystallography Commentary to Ortega-Sáenz P, López-Barneo J. Physiology of the Carotid Body: From Molecules to Disease. Annu Rev Physiol 82: 127–149, 2020. Torres-Torrelo H, Ortega-Sáenz P, Gao L, López-Barneo J. Lactate sensing mechanisms in arterial chemoreceptor cells. Nat Commun 12: 4166, 2021
- Source :
-
Pflügers Archiv: European Journal of Physiology . Feb2022, Vol. 474 Issue 2, p187-189. 3p. - Publication Year :
- 2022
-
Abstract
- Carotid body physiology meets cytochrome c oxidase crystallography Commentary to Ortega-Sáenz P, López-Barneo J. Physiology of the Carotid Body: From Molecules to Disease. Changing gas composition of the super-fusion medium from 20% O SB 2 sb , 3% CO SB 2 sb , 77% N SB 2 sb (normoxia) to 97% N SB 2 sb , 3% CO SB 2 sb (full hypoxia) is followed by a characteristic hypoxia-induced increased chemoreceptor sinus nerve activity (registration in black) serving as control. 1 CcO crystallographic changes of about 3 Ångström are displayed by CB chemoreceptor discharge. a Chemoreceptor discharge under normoxic and hypoxic CO application (red registration line) The effect of CO is shown as a percentage of peak chemoreceptor activity induced by 4-min hypoxia. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00316768
- Volume :
- 474
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Pflügers Archiv: European Journal of Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 154738885
- Full Text :
- https://doi.org/10.1007/s00424-021-02662-8