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Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma.

Authors :
Cooke, Mariana
Source :
Molecular & Cellular Oncology. 2021, Vol. 8 Issue 6, p1-3. 3p.
Publication Year :
2021

Abstract

In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation of membrane ruffles in response to growth factor receptor stimulation. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*PHENOTYPES
*ADENOCARCINOMA
*METASTASIS
*LUNG cancer
*TYROSINE

Details

Language :
English
ISSN :
23723556
Volume :
8
Issue :
6
Database :
Academic Search Index
Journal :
Molecular & Cellular Oncology
Publication Type :
Academic Journal
Accession number :
154794097
Full Text :
https://doi.org/10.1080/23723556.2021.2013723
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