New chemistries for the control of human head lice, Pediculus humanus capitis: A mini-review.

Pediculus lice represent one of the longest and most prevalent parasitic infestations of humans. Head lice are an economic and social concern whereas body lice pose a more serious public health threat. Significant progress has been made in the study of human lice over the last 10 years, allowing for new approaches in their control. An in vitro rearing system has made it possible to maintain insecticide-susceptible and -resistant reference strains, which allowed an in depth study of pediculicide resistance, including its underlying molecular mechanisms and the detection and monitoring of resistance. The generation of inbreed strains facilitated the efficient sequencing, assembly and annotation of the genomes and transcriptomes of both lice. The use of functional genomics and reverse genetics elucidated the genetics involved in the evolution of resistance and the discovery of novel target sites for the development of new pediculicides. In this review, four new effective pediculicide products, each with different mode of action and unique chemistries, will be presented. They have been found to be safe and selective, and control resistant lice. As such, they meet the criteria necessary to be used in rotations as a sustainable resistance management strategy. [Display omitted] • Head lice are resistant to permethrin/pyrethrins due to 3 kdr -type mutations. • Also resistant to malathion due to enhanced malathion carboxylesterase activity. • Four new pediculicides products kill resistant lice. • Each has novel chemistry and different modes of action. • Their use in rotations is suggested as an effective resistance management strategy. [ABSTRACT FROM AUTHOR]