宫腔镜下冷刀分离术与电切术治疗宫腔粘连的疗效及对宫腔形态恢复和血清白细胞介素的影响.

Objective: To compare the efficacy of hysteroscopic cold knife separation and electrotomy in the treatment of intrauterine adhesion (IUA) and its effect on the recovery of intrauterine morphology and serum interleukin. Methods: The clinical data of 83 patients with IUA who were treated in our hospital from April 2019 to February 2021 were analyzed retrospectively. According to the different operation methods, the patients were divided into group A (electrosurgical resection under hysteroscopy, 40 cases) and group B (cold knife separation under hysteroscopy, 43 cases). The operation time and hospital stay, the recovery of uterine morphology and the changes of serum interleukin were compared between the two groups. The incidence of postoperative complications, the improvement rate of menstruation and the incidence of uterine re adhesion were observed. Results: The operation time and hospital stay in group B were shorter than those in group A(P<0.05). The total effective rate and satisfactory rate of epithelial healing of intimal wound in group B were higher than those in group A(P<0.05). The levels of serum interleukin-6 (IL-6) and interleukin-8 (IL-8) in group B were higher than those in group A (P<0.05). The levels of serum interleukin-4 (IL-4) and interleukin-10 (IL-10) in group B were lower than those in group A (P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P>0.05). The improvement rate of menstruation in group B was higher than that in group A, and the incidence of uterine re adhesion was lower than that in group A(P<0.05). Conclusions: Compared with hysteroscopic electrotomy in the treatment of IUA, hysteroscopic cold knife separation in the treatment of IUA has shorter operation time and hospital stay, better recovery of uterine morphology and improvement of menstruation, milder inflammatory reaction, lower incidence of uterine re adhesion and better curative effect. [ABSTRACT FROM AUTHOR]