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Screening of Biological Target Molecules Related to Glucocorticoid-Induced Cataract (GIC) on the Basis of Constructing ceRNA Network.
- Source :
-
Biochemical Genetics . Feb2022, Vol. 60 Issue 1, p24-38. 15p. - Publication Year :
- 2022
-
Abstract
- Glucocorticoid-induced cataract (GIC)-associated biomarkers were screened by ceRNA network construction. The GIC samples' GSE3040 were obtained from the NCBI-GEO database. R's Limma package was used to identify differentially expressed RNAs (DERs) between the normal and GIC samples group (4- and 16-h). The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analysis for the mRNAs in the constructed GIC lncRNA–miRNA–mRNA ceRNA regulation network was implemented. A total of 1665 and 1443 DERs were obtained in the 4- and 16-h group, respectively. At two time points, 256 overlapping DERs were identified, of which 210 (17 lncRNAs and 203 mRNAs) had significant differential expression (4 down- and 206 up-regulated). A total of 534 co-expressed ligation pairs (all up-regulated) were obtained. A ceRNA regulation network was constructed. RPS6KA5, GAB1, CCR7, CCL2, COL4A4, and PPARG were obtained and significantly enriched in the 4 KEGG signaling pathways and were featured as GIC target molecules. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00062928
- Volume :
- 60
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 154880483
- Full Text :
- https://doi.org/10.1007/s10528-021-10078-3