Mechanism of Tingli Dazao Xiefei Decoction in the Treatment of COPD Based on Network Pharmacology and Molecular Docking Technology.

[Objectives] The action mechanism of Tingli Dazao Xiefei Decoction in the treatment of COPD was explored by the network pharmacology and molecular docking technology. [Methods] The TCMSP database was used to perform active ingredient screening and target prediction on Chinese medicines contained in Tingli Dazao Xiefei Decoction, and COPD-related targets were searched through disease databases. Common targets of Tingli Dazao Xiefei Decoction and COPD were imported into Metascape database for GO analysis and KEGG pathway enrichment analysis. The STRING database was used to perform PPI analysis on common targets, and core targets were screened through the Cyto-scape software. The Pymol, AutoDockTools, Vina and other software were used for molecular docking of some core targets and ingredients. [Results] From Tingli Dazao Xiefei Decoction, 26 active ingredients which shared 211 common targets and 22 core targets with COPD, were screened out. Enrichment analysis revealed a total of 1 892 biological processes, 78 cell components, 152 molecular functions, and 164 signal paths. The molecular docking of part of the core targets and corresponding ingredients obtained beeter results. [Conclusions] Tingli Dazao Xiefei Decoction treats COPD through multiple targets and multiple pathways, revealing its mechanism for treating COPD. [ABSTRACT FROM AUTHOR]