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A mechanism for improved talc pleurodesis via foam delivery.
- Source :
-
Drug Delivery . 2021, Vol. 28 Issue 1, p733-740. 8p. - Publication Year :
- 2021
-
Abstract
- Talcum powder is recognized as the leading drug for pleurodesis, a treatment of choice for malignant pleural effusions. Recently, it was shown that hydrogel foam delivery systems significantly enhanced the number of adhesions between the chest wall and the lung in a New Zealand rabbit model due to the sol-gel transition. However, many questions still remain regarding the cause of improved efficacy, such as: (1) Would only hydrogel foams improve the efficacy of talc pleurodesis? (2) Is it possible to achieve the same efficacy of hydrogels using non-hydrogel foams? 3) What are the physicochemical properties that can be correlated to the efficacy of talc pleurodesis? In this study, we use non-hydrogel foam formulations to determine the efficacy of pleurodesis. Foam stability and rheology of the formulations were correlated to adhesion formation. The results clearly suggest a correlation of pleurodesis efficacy to the viscosity and modulus of the foam delivery system. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FOAM
*PLEURODESIS
*TALC
*BABY powders
*PLEURAL effusions
*RHEOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 10717544
- Volume :
- 28
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Drug Delivery
- Publication Type :
- Academic Journal
- Accession number :
- 154908521
- Full Text :
- https://doi.org/10.1080/10717544.2021.1895910