Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine.

The author discusses molecular oxygen sensing mechanisms in human cells and their medical implications in 2022. Topics covered include the quest for cellular oxygen-sensing mechanisms, oxygen sensing in human and animal cells, and the transcription hypoxia-induced factor (HIF) in hepatoma cells around the erythropoietin control sequences that is oxygen-dependent. Also noted are these agents' potential in treating von Hippel-Lindau (VHL)-defective renal carcinoma and hereditary VHL disease.