Abstracts of A Presentation by the winners of The Japanese Society of Pathology; Pathology Research Award in 2021 (in program order).

These findings provide valuable insights on the mechanisms of ESCC progression mediated by cell-cell interactions among cancer cells, TAMs and CAFs in the tumor microenvironment. I have studied "the significance of cell-cell interactions between tumor cells and stromal cells" in the tumor microenvironment. Subsequent investingations on NKX2.2-negative non-Ewing round cell sarcomas evolved into detailed characterization of CIC-rearranged sarcoma and "SMARCA4-deficient thoracic sarcoma", which helped in establishing these tumor concepts. [Extracted from the article]