A fluorogenic RNA aptamer nanodevice for the low background imaging of mRNA in living cells.

A fluorogenic RNA aptamer nanodevice integrating an entropy-driven RNA amplifier with near-infrared (NIR) light control was developed, affording high contrast and sensitivity for imaging low-abundance mRNA in living cells. The design principle offers a new approach for developing low-background imaging systems for live-cell studies and manipulation. [ABSTRACT FROM AUTHOR]