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Neutralizing SARS-CoV-2 by dimeric side chain-to-side chain cross-linked ACE2 peptide mimetics.
- Source :
-
Chemical Communications . 2/7/2022, Vol. 58 Issue 11, p1804-1807. 4p. - Publication Year :
- 2022
-
Abstract
- We present the finding of a dimeric ACE2 peptide mimetic designed through side chain cross-linking and covalent dimerization. It has a binding affinity of 16 nM for the SARS-CoV-2 spike RBD, and effectively inhibits the SARS-CoV-2 pseudovirus in Huh7-hACE2 cells with an IC50 of 190 nM and neutralizes the authentic SARS-CoV-2 in Caco2 cells with an IC50 of 2.4 μM. Our study should provide a new insight for the optimization of peptide-based anti-SARS-CoV-2 inhibitors. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDES
*ANGIOTENSIN converting enzyme
*SARS-CoV-2
*DIMERIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 155052124
- Full Text :
- https://doi.org/10.1039/d1cc06301d