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Post-treatment heterogeneity of cardiometabolic risk in patients with acromegaly: The impact of GH and IGF-1.
- Source :
-
Endocrine Research . Feb 2022, Vol. 47 Issue 1, p1-7. 7p. - Publication Year :
- 2022
-
Abstract
- Metabolic abnormalities are frequently seen in patients with acromegaly. However, it is not clear to what extent growth hormone/insulin-like growth factor-1 (GH/IGF-1) contributes to the development of these abnormalities. This study aimed to explore the impact of postoperative GH/IGF–1 on different aspects of metabolic abnormalities in patients with acromegaly. This retrospective, registry-based study conducted on 102 patients with acromegaly. The impact of GH/IGF-1 on the cardiometabolic risk factors at 3–12 months after surgery has been investigated using linear and logistic regression models. In this study, each 1 ng/ml increase in the level of GH was significantly associated with a 2 mg/dl increase in the level of fasting blood glucose (FBG), a 0.5 mmHg increase in the level of systolic blood pressure (SBP), and a 0.9 mmHg increase in the level of diastolic blood pressure (DBP). Upon multivariate analysis, GH, but not IGF-1, significantly increased the odds of diabetes mellitus (DM) (OR; 1.2, 95% CI; 1.0–1.4, p =.025). Our findings indicated at early postoperative stage, GH is significantly associated with the levels of FBG, SBP, and DBP. Moreover, GH, but not IGF-1, appears as a predictive factor for the presence of DM. However, neither GH nor IGF-1 could predict the presence of hypertension HTN, or dyslipidemia in this study. CVD: Cardiovascular disease; GH: Growth hormone; IGF-1: Insulin-like growth factor 1; BMI: Body mass index; HTN: hypertension; IPTR: Iran Pituitary Tumor Registry; WC: Waist circumference; MRI: Magnetic resonance imaging; FBG: Fasting blood glucose; HbA1C: Glycated hemoglobin; TG: Triglyceride; LDL: Low density lipoprotein; HDL: High density lipoprotein; SBP: Systolic blood pressure; DBP: Diastolic blood pressure [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07435800
- Volume :
- 47
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Endocrine Research
- Publication Type :
- Academic Journal
- Accession number :
- 155104951
- Full Text :
- https://doi.org/10.1080/07435800.2021.1931298