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Regeneration of Phytochemicals by Structure‐Driven Organization of Microbial Biosynthetic Steps.

Authors :
Wu, Xue Ming
Guan, Qiu Yan
Han, Yun Bin
Wang, Xin Cun
Zhuang, Wen Ying
Tan, Ren Xiang
Source :
Angewandte Chemie International Edition. 2/14/2022, Vol. 61 Issue 8, p1-7. 7p.
Publication Year :
2022

Abstract

Medicinal phytochemicals, such as artemisinin and taxol, have impacted the world, and hypericin might do so if its availability issue could be addressed. Hypericin is the hallmark component of Saint John's wort (Hypericum perforatum L.), an approved depression alleviator documented in the US, European, and British pharmacopoeias with its additional effectiveness against diverse cancers and viruses. However, the academia‐to‐industry transition of hypericin remain hampered by its low in planta abundance, unfeasible bulk chemical synthesis, and unclear biosynthetic mechanism. Here, we present a strategy consisting of the hypericin‐structure‐centered modification and reorganization of microbial biosynthetic steps in the repurposed cells that have been tamed to enable the designed consecutive reactions to afford hypericin (43.1 mg L−1), without acquiring its biosynthetic knowledge in native plants. The study provides a synthetic biology route to hypericin and establishes a platform for biosustainable access to medicinal phytochemicals. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14337851
Volume :
61
Issue :
8
Database :
Academic Search Index
Journal :
Angewandte Chemie International Edition
Publication Type :
Academic Journal
Accession number :
155106460
Full Text :
https://doi.org/10.1002/anie.202114919