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YES-10 Improves Stress, Tension, and Fatigue by Reducing Cortisol and IL-6 Levels.
- Source :
-
Journal of Medicinal Food . Feb2022, Vol. 25 Issue 2, p205-212. 8p. - Publication Year :
- 2022
-
Abstract
- The extract of Clematis mandshurica Rupr. (CMR) inhibits the production of proinflammatory mediators from lipopolysaccharide-stimulated peritoneal macrophages and concanavalin A-stimulated splenocytes. Erigeron annuus Pers. (EAP) extract suppresses the production of reactive oxygen species (ROS) from preadipocytes. Furthermore, the mixture of the leaf extracts of CMR and EAP, YES-10®, protected against nerve injuries induced by ischemia/reperfusion, suggesting a ROS-scavenging action. These observations show the anti-inflammatory action of YES-10. Inflammatory cytokines can cause alterations in mental function, including depression, by influencing the neurotransmitter system. Thus, it was hypothesized that YES-10 could improve mental health, such as depression, anxiety, and sense of well-being. Seventy-two subjects were recruited and randomly divided into YES-10 or placebo groups (n = 36 per group). Each group was daily administered two capsules orally, containing 200 mg of YES-10 or placebo, for 4 weeks in a double-blinded manner and tested for levels of depression, anxiety, well-being, and mental fitness using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Psychosocial Well-being Index (PWI), and Mental Fitness Scale (MFS). In addition, the levels of cortisol (a stress hormone), interleukin-6 (IL-6) (an inflammatory cytokine), and 8-hydroxydeoxyguanosine (8-OHdG; a marker of oxidative stress) in the serum were measured. The BDI, BAI, PWI, and MFS scores decreased significantly, and the serum levels of cortisol, IL-6, and 8-OHdG were lowered significantly (P < .05), suggesting that YES-10 has the ability to improve mental health by relieving stress and by decreasing inflammation and oxidative stress. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERLEUKINS
*ISCHEMIA
*CYTOKINES
*NEUROTRANSMITTERS
*MENTAL health
*RANDOMIZED controlled trials
*PSYCHOLOGICAL tests
*OXIDATIVE stress
*LEAVES
*MENTAL depression
*DRUGS
*FATIGUE (Physiology)
*PLANT extracts
*REACTIVE oxygen species
*REPERFUSION
*ANXIETY
*STATISTICAL sampling
*PSYCHOLOGICAL stress
*HYDROCORTISONE
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1096620X
- Volume :
- 25
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Medicinal Food
- Publication Type :
- Academic Journal
- Accession number :
- 155187234
- Full Text :
- https://doi.org/10.1089/jmf.2021.K.0129