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The association between vitamin D and uveitis: A comprehensive review.
- Source :
-
Survey of Ophthalmology . Mar2022, Vol. 67 Issue 2, p321-330. 10p. - Publication Year :
- 2022
-
Abstract
- Vitamin D plays an important role in both the innate and adaptive immune systems. We review published data on the relationship between uveitis and vitamin D levels or vitamin D-associated gene polymorphisms. A search of the PubMed and Medline databases was conducted to identify relevant articles concerning vitamin D and uveitis. Sixteen studies were included in this review, and the evidence they present, linking low vitamin D levels with uveitis, is compelling. The uveitic entities shown to be modulated by hypovitaminosis D include, but are not limited to, HLA-B27-associated acute anterior uveitis, Vogt-Koyanagi-Harada (VKH) disease, sarcoidosis-associated uveitis, and juvenile idiopathic arthritis-associated uveitis. Specific polymorphisms of vitamin D family genes were found to correlate with uveitis in ankylosing spondylitis, Behçet's disease, VKH, and HLA B27-positive patients. Further understanding of the role of vitamin D, a known regulator of inflammatory processes, in noninfectious uveitis may advance capabilities in the fields of disease prevention and treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D
*BEHCET'S disease
*UVEITIS
*INFLAMMATION
*IRIDOCYCLITIS
Subjects
Details
- Language :
- English
- ISSN :
- 00396257
- Volume :
- 67
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Survey of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 155285330
- Full Text :
- https://doi.org/10.1016/j.survophthal.2021.07.006