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Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE.
- Source :
-
Journal of Alzheimer's Disease . 2022, Vol. 85 Issue 4, p1573-1582. 10p. - Publication Year :
- 2022
-
Abstract
- <bold>Background: </bold>Subjective cognitive decline (SCD), an at-risk condition of Alzheimer's disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention.<bold>Objective: </bold>We aim to explore the difference in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition.<bold>Methods: </bold>A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and 18F-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD (n = 34) and sd-SCD (n = 29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition.<bold>Results: </bold>Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr (F = 5.033, p = 0.029) and regional amyloid SUVr in the left middle temporal gyrus (F = 12.309, p = 0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores.<bold>Conclusion: </bold>According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COGNITION disorders
*AMYLOID
*EPISODIC memory
*MULTIPLE regression analysis
*POSITRON emission tomography
*TEMPORAL lobe
*CLINICAL neuropsychology
*PROTEIN metabolism
*BRAIN
*RESEARCH
*RESEARCH methodology
*EVALUATION research
*NEUROPSYCHOLOGICAL tests
*COMPARATIVE studies
*EMISSION-computed tomography
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 85
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 155334013
- Full Text :
- https://doi.org/10.3233/JAD-215373