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A novel sustained release fluoride strip based Poly(propylene carbonate) for preventing caries.
- Source :
-
European Journal of Pharmaceutical Sciences . Apr2022, Vol. 171, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- Low-level fluoride in the oral environment for a long sustained period is more effective for preventing caries. However, the current fluoride delivery methods have a short fluoride retention time and high-dose fluoride administration may increase the risk of dental fluorosis. This study developed a novel fluoride strip based poly(propylene carbonate) (PPC), which can improve oral fluoride retention for desirable anticaries effect with minimal side effects. The fluoride strips based PPC (NaF-PPC strips) with different fluoride contents (0, 1.25, 2.5 and 5 wt.%) were developed by melt-blending method. The physico-chemical characteristics, drug loading, drug release properties, remineralization and antibacterial efficacy and biocompatibility of NaF-PPC strips were investigated. The in vitro drug release studies indicated that fluoride release in a sustained manner with no initial burst release and approximately 100% of fluoride ions were released from PPC strips over 24 days. NaF-PPC strips exhibited excellent remineralization and antibacterial potential when fluoride content up to 5%. Combination with biocompatibility, 2.5% NaF-PPC strips could be a promising fluoride application for preventing caries. This work provides an effective and novel topical fluoride delivery for general use. [Display omitted] [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROPYLENE carbonate
*FLUORIDES
*FLUOROSIS
*RF values (Chromatography)
Subjects
Details
- Language :
- English
- ISSN :
- 09280987
- Volume :
- 171
- Database :
- Academic Search Index
- Journal :
- European Journal of Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 155339227
- Full Text :
- https://doi.org/10.1016/j.ejps.2022.106128