The influence of gestational age and neurological status of premature infants on hemostasis.

Hemostasis disorders in preterm infants occur more often than in full-term ones due to the immaturity of the coagulation system, and lead to the appearance of hemorrhagic syndrome [1, 2]. Various forms of blood coagulation disorders in newborns can be both primary, with independent nosological significance, and secondary, if they are an intermediate link in the pathogenesis of many serious diseases and processes, significantly affecting the course and outcomes, making the main pathogenetic therapy ineffective [3]. Monitoring of hemostasis indices is necessary both timely assessment and preclinical diagnosis of hemorrhagic and thrombotic manifestations, and for evaluating the effectiveness of treatment. To assess such deviations, it is necessary to know the normative indicators of hemostasis, which are determined for full-term, but to a lesser extent - for premature infants. Of particular importance for the correct assessment of hemostatic disorders is the knowledge of the characteristics of changes in hemostasiological parameters in the dynamics of the early neonatal period. Currently, they defined for full-term [4, 5] and to a lesser extent for premature newborns [6]. Currently, there are no comprehensive data on hemostasis in preterm infants performed on modern analytical systems, and therefore the goal of this work was to refine the characteristics of plasma hemostasis in preterm infants taking into account their gestational age (GA). [ABSTRACT FROM AUTHOR]