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Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus.
- Source :
-
Evolutionary Bioinformatics . 2019, p1-6. 6p. - Publication Year :
- 2019
-
Abstract
- We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diversified variants and a strong positive selection in the patient, indicating that such patients may be a reservoir for astrovirus. The time to the most recent common ancestor of MLB2 and classic HAstVs was around 1800 years, and it has a decline in effective population size of HAstVs in the late 100 years. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEMATOPOIETIC stem cell transplantation
*IMMUNOCOMPROMISED patients
Subjects
Details
- Language :
- English
- ISSN :
- 11769343
- Database :
- Academic Search Index
- Journal :
- Evolutionary Bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 155437964
- Full Text :
- https://doi.org/10.1177/1176934319864922