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Assessing K+ ions and K+ channel functions in cancer cell metabolism using fluorescent biosensors.
- Source :
-
Free Radical Biology & Medicine . Mar2022, Vol. 181, p43-51. 9p. - Publication Year :
- 2022
-
Abstract
- Cancer represents a leading cause of death worldwide. Hence, a better understanding of the molecular mechanisms causing and propelling the disease is of utmost importance. Several cancer entities are associated with altered K+ channel expression which is frequently decisive for malignancy and disease outcome. The impact of such oncogenic K+ channels on cell patho-/physiology and homeostasis and their roles in different subcellular compartments is, however, far from being understood. A refined method to simultaneously investigate metabolic and ionic signaling events on the level of individual cells and their organelles represent genetically encoded fluorescent biosensors, that allow a high-resolution investigation of compartmentalized metabolite or ion dynamics in a non-invasive manner. This feature of these probes makes them versatile tools to visualize and understand subcellular consequences of aberrant K+ channel expression and activity in K+ channel related cancer research. [Display omitted] • K+ ions and K+ channels modulate cancer malignancy. • K+ channels are located throughout (intra-) cellular membranes. • Fluorescent biosensors allow high resolution imaging of subcellular signaling events. • Biosensors are valuable tools to investigate metabolic consequences of oncogenic K+ channels. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08915849
- Volume :
- 181
- Database :
- Academic Search Index
- Journal :
- Free Radical Biology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 155457708
- Full Text :
- https://doi.org/10.1016/j.freeradbiomed.2022.01.026