Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms.

The article reports the deletion of AUTS2, a high-susceptibility gene of ASDs, caused postnatal dentate gyrus (DG) hypoplasia, which was closely relevant to social recognition deficit. It discusses that the supramammillary nucleus (SuM)–DG-CA3 neural circuit was found to be involved in social recognition and affected in Auts2-deleted mice due to DG hypoplasia; and mentions that it demonstrated the vital role of Auts2 in postnatal DG development.