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Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms.
- Source :
-
Science Advances . 3/4/2022, Vol. 8 Issue 9, p1-19. 19p. - Publication Year :
- 2022
-
Abstract
- The article reports the deletion of AUTS2, a high-susceptibility gene of ASDs, caused postnatal dentate gyrus (DG) hypoplasia, which was closely relevant to social recognition deficit. It discusses that the supramammillary nucleus (SuM)–DG-CA3 neural circuit was found to be involved in social recognition and affected in Auts2-deleted mice due to DG hypoplasia; and mentions that it demonstrated the vital role of Auts2 in postnatal DG development.
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 8
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Science Advances
- Publication Type :
- Academic Journal
- Accession number :
- 155572140
- Full Text :
- https://doi.org/10.1126/sciadv.abk1238