"Are you gonna go my way?"—Decisions at the Tfh-B cell interface.

The generation of memory B cells and plasma cells is complex and involves inputs from the microenvironment, notably from T follicular helper cells. In last month's issue of Immunity , Yeh et al. and Song et al. refine our understanding of the B cell intrinsic and extrinsic requirements to generate effective humoral immunity in response to foreign antigens. [ABSTRACT FROM AUTHOR]