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Silver-catalyzed cyclopropanation of alkenes with alkynyl N-nosylhydrazones leading to alkynyl cyclopropanes.
- Source :
-
Chemical Communications . 3/14/2022, Vol. 58 Issue 21, p3485-3488. 4p. - Publication Year :
- 2022
-
Abstract
- Here, a novel method for the stereoselective synthesis of alkynyl cyclopropanes, by the silver-catalyzed alkynylcyclopropanation of alkenes using alkynyl N-nosylhydrazones as alkynyl carbene precursors, is reported. This method provides a straightforward and powerful approach for preparing various alkynyl cyclopropanes in high yield with excellent stereoselectivities. In addition, the practicality of this method was demonstrated by gram-scale synthesis and late-stage modification of bioactive molecules. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYCLOPROPANATION
*ALKENES
*CYCLOPROPENE
*STEREOSELECTIVE reactions
*MOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 155685190
- Full Text :
- https://doi.org/10.1039/d2cc00099g