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Construction of a new immune-related lncRNA model and prediction of treatment and survival prognosis of human colon cancer.

Authors :
Liu, Sicheng
Peng, Xingyu
Wu, Xun
Bu, Fanqin
Yu, Zhonglin
Zhu, Jinfeng
Luo, Chen
Zhang, Wenjun
Liu, Jiang
Huang, Jun
Source :
World Journal of Surgical Oncology. 3/6/2022, Vol. 20 Issue 1, p1-12. 12p.
Publication Year :
2022

Abstract

Background: An increasing number of studies have shown that immune-related long noncoding RNAs (lncRNAs) do not require a unique expression level. This finding may help predict the survival and drug sensitivity of patients with colon cancer. Methods: We retrieved original transcriptome and clinical data from The Cancer Genome Atlas (TCGA), sorted the data, differentiated mRNAs and lncRNAs, and then downloaded immune-related genes. Coexpression analysis predicted immune-related lncRNAs (irlncRNAs) and univariate analysis identified differentially expressed irlncRNAs (DEirlncRNAs). We have also amended the lasso pending region. Next, we compared the areas under the curve (AUCs), counted the Akaike information standard (AIC) value of the 3-year receiver operating characteristic (ROC) curve, and determined the cutoff point to establish the best model to differentiate the high or low disease risk group of colon cancer patients. Results: We reevaluated the patients regarding the survival rate, clinicopathological features, tumor-infiltrating immune cells, immunosuppressive biomarkers, and chemosensitivity. A total of 155 irlncRNA pairs were confirmed, 31 of which were involved in the Cox regression model. After the colon cancer patients were regrouped according to the cutoff point, we could better distinguish the patients based on adverse survival outcomes, invasive clinicopathological features, the specific tumor immune cell infiltration status, high expression of immunosuppressive biomarkers, and low chemosensitivity. Conclusions: In this study, we established a characteristic model by pairing irlncRNAs to better predict the survival rate, chemotherapy efficacy, and prognostic value of patients with colon cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14777819
Volume :
20
Issue :
1
Database :
Academic Search Index
Journal :
World Journal of Surgical Oncology
Publication Type :
Academic Journal
Accession number :
155687825
Full Text :
https://doi.org/10.1186/s12957-022-02508-2