Toxicity and Local Irritation Action of the Biomedical Cell Product Anti-HER2-CAR-T-NK Upon Multiply Repeated Administration.

Authors :: Goryacheva, N. A.
Rzhevskii, D. I.
Slashcheva, G. A.
Novikova, N. I.
Kiselevskii, M. V.
Chikileva, I. O.
Vlasenko, R. Ya.
Murashev, A. N.
Bondarenko, D. A.
Source :: Pharmaceutical Chemistry Journal. Mar2022, Vol. 55 Issue 12, p1276-1281. 6p.
Publication Year :: 2022
Abstract: CAR-cell therapy is a promising new method of cancer treatment. The biomedical cell product Anti-HER2-CAR-T-NK cells has been found safe in a course of intraperitoneal injection at a human-equivalent therapeutic dose in male and female ICR mice. The obtained information can help in the future to form the basis of recommendations for preclinical studies of CAR-cell immunopreparations. [ABSTRACT FROM AUTHOR]

Subjects :: *LABORATORY mice
*INTRAPERITONEAL injections
*CANCER treatment
*CHIMERIC antigen receptors

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