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Decellularized Alstroemeria flower stem modified with chitosan for tissue engineering purposes: A cellulose/chitosan scaffold.
- Source :
-
International Journal of Biological Macromolecules . Apr2022, Vol. 204, p321-332. 12p. - Publication Year :
- 2022
-
Abstract
- Utilizing plant-based scaffolds has pulled in the consideration of tissue engineers. Plant tissues own different structures with particular porosity and structure. In this study, the stem of the Alstroemeria flower was designated for decellularization to fabricate a new scaffold. The stems were decellularized and called AFSP and then modified by chitosan and named AFSPC. Osteoblast precursor cell line was employed to assess the biological potential of the final scaffolds. The results uncovered that AFSP owns linear microchannels with a smooth surface. AFSPC delineated uniform chitosan coating on the walls with appropriate roughness. AFSPC showed higher potential in swelling, degradation, diffusion, and having a porous structure than AFSP. Modification with chitosan improved mechanical behavior. Biological assays depicted no cytotoxicity for AFSP and AFSPC. AFSPC showed good cell attachment, proliferation, and migration. In conclusion, modified tissue plants can be a good candidate for tissue engineering of both soft and hard tissues. [Display omitted] • Stems of plants own linear microchannels that can act as vessels in scaffolds. • Decellularized plant was modified with chitosan for biological properties improvement. • Modification with chitosan promoted the mechanical behavior. • MC3T3 cells could migrate into the central zones due to the microchannel. • This type of plant-based scaffold can be a good candidate for bone tissue engineering. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 204
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 155723853
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2022.02.019